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Important Information on Nephrogenic Systemic Fibrosis (NSF)
November 20th, 2009

Mayo Clinic Study Finds Higher Risk of NSF Among Kidney Transplant, Dialysis Patients

A study recently published in the Archives of Dermatology has found that kidney transplant and dialysis patients face a much higher risk of developing nephrogenic systemic fibrosis (NSF) than other patients exposed to gadolinium contrast dyes.

The study involved 94,917 patients exposed to gadolinium agents at the Mayo Clinic between January 1, 1999 and December 31, 2006.   Of that group, 3,779 patients were on hemodialysis, 1,694 patients had undergone a kidney transplant, and 717 patients had liver transplants.  A total of 61 patients had a clinical diagnosis of NSF.

Overall, the dialysis patients faced a 77-fold higher risk of NSF, while kidney transplant patients had a 69-fold higher risk of the disease.

The study authors advocated for the development of new guidelines for the administration of gadolinium agents.

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